KPV

KPV

10mg Research use only

$45.00

Tripeptide Lys-Pro-Val, the C-terminal fragment (residues 11–13) of alpha-melanocyte-stimulating hormone (α-MSH). Supplied as a lyophilized powder.

Bulk pricing: 3+ save 30% · 5+ save 35% · 10+ save 60%, automatically.

Free shipping on orders over $125

  • Lab tested
  • Research grade
  • High purity
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For research use only. Not for human consumption, medical, veterinary or diagnostic use.

Overview

KPV (L-lysyl-L-prolyl-L-valine) is a naturally occurring tripeptide that forms the C-terminal end (residues 11–13) of alpha-melanocyte-stimulating hormone (α-MSH). Researchers study it because, in experimental models, it keeps much of the anti-inflammatory activity of the full α-MSH hormone while lacking the part of the molecule associated with pigmentation.

How it works in laboratory studies: KPV is taken up into cells through PepT1, a peptide transporter found on intestinal lining cells and immune cells. Inside the cell, it has been shown to reduce activation of the NF-κB and MAP kinase signaling pathways, which switch on the production of inflammatory messengers (cytokines) such as IL-6, IL-8 and TNF-α.

Areas of research: in mouse models of colitis, orally given KPV reduced markers of intestinal inflammation. It has also been studied in skin and wound-healing models, and early laboratory work reported antimicrobial activity against Staphylococcus aureus and Candida albicans.

These findings come from cell and animal studies. KPV is supplied for laboratory research only and is not approved for human or veterinary use.

Specifications